Overview

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Eugene Braunwald, MD, a member of Broadview’s Strategic Advisory Board, is the Distinguished Hersey Professor of Medicine at Harvard Medical School, and Chairman of the TIMI Study Group at the Brigham and Women’s Hospital.

Dr. Braunwald’s first major paper was published in Circulation Research in July 1954, and he has been a major force in cardiology in the past half century. His early work focused on the control of ventricular function and he was the first to measure both left ventricular ejection fraction and left ventricular dp/dt in patients. His group showed the first neurohumoral defect in human heart failure, defined the pathophysiology of hypertrophic cardiomyopathy and demonstrated salvage of ischemic myocardium following coronary occlusion. They defined myocardial stunning and ventricular modeling following myocardial infarction. For the past 24 years, as Chairman of the TIMI Study Group, he and his colleagues demonstrated improved patient survival with a patent coronary artery which led to the widely accepted “open artery hypotheses.” They were the first to show the benefit of preventing adverse remodeling of the infarcted ventricle with ACE inhibition. In the PROVE-IT TIMI 2 Trial, in 2004, they demonstrated the benefit of more intensive reduction of LDL in high risk coronary artery patients, which has already changed practice guidelines and will favorably affect the lives of millions.

Dr. Braunwald is an editor of Harrison’s Principles of Internal Medicine, and the founding editor of Heart Disease, now in its 8th Edition, the most influential textbooks in their fields.